Pediatric Solid Tumors:
Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is an ultrasound-based technology that can raise temperature under the guidance of MR. MR-HIFU delivers safe, precise and controlled heating by focusing ultrasound energy inside a lesion, without the need for a scalpel or needle. Advantages over conventional local tumor control methods such as surgery or radiation are that MR-HIFU is non-invasive and non-ionizing.
HIFU has been applied to treat a variety of solid tumors in adults, including ablative therapy for uterine fibroids, breast, pancreas, and soft-tissue sarcomas, and for relief of pain from bone metastases. Clinical trials in adults thus far have demonstrated HIFU to be safe and well tolerated with minimal complications treatment.
Osteoid Osteoma in Children
Osteoid Osteoma (OO) is a benign, but painful, bone tumor commonly occurring in children and young adults. Treatment options include surgical excision or, more commonly, CT-guided radiofrequency ablation (RFA). RFA is less invasive than surgery, but still requires drilling from the skin through muscle and soft tissue into bone. It also exposes the patient and operator to ionizing radiation.
Magnetic Resonance guided High Intensity Focused Ultrasound (MR-HIFU) provides precise and controlled delivery of focused ultrasound energy (heat) to a targeted lesion using an external applicator, without the need for a scalpel or needle. MR-HIFU has been successfully used to treat painful bone metastases in adult clinical trials and one recent report suggests that it can also be used to treat OO.