Development of Novel Non-Invasive Growth Plate Ablation Treatment for Children with Limb-Length Discrepancy Using MR-Guided High-Intensity Focused Ultrasound

Discrepancy in lower limb lengths in children is a common condition, with as many as 40% of children affected. If untreated, in ≈8% of all children, the condition may lead to a noticeable limping, lower back pain, scoliosis, poor posture, osteoarthritis of the hip and spine, lower extremity stress …

Optimization of Treatment Planning of Non-Invasive Therapy with MR-HIFU

This project aims to address a clearly identified need to improve patient positioning and pre-planning of treatment with MR-HIFU. Current clinical trials of MR-HIFU treatments typically rely on approximate patient positioning based on the general location of the disease to be targeted  …

Optimization of Combination of Ablative and Non-Ablative Hyperthermia and Drug Delivery for Complete Treatment of Solid Tumors in Pediatric Patients

The phase I clinical trial of ablative treatment of pediatric solid tumors is an important step towards establishing MR-HIFU as a non-invasive treatment option. However, a significant portion of the pediatric population with such tumors may benefit more from a treatment that includes …

Treatment of Prenatal Bladder Outlet Obstruction Using Non-Invasive Vesicostomy with High-Intensity Focused Ultrasound

Bladder outlet obstruction is a common congenital defect that can cause serious damage to a child even before he or she is born. The team proposes a novel preclinical application of HIFU with an external transducer …

Immunogenic Effects of MR-HIFU in Pediatric Oncology

While immunogenic effects of MR-HIFU have been reported in a number of animal studies, pre-clinical data does not illuminate how such effects may be used in pediatric oncology. Our group is working with the CNMC Immunology …